LSD CRYSTAL CAN BE FUN FOR ANYONE

During the LSD-certain crystal construction, the side chain in the lid residue L209EL2 forms substantial hydrophobic contacts with both LSD and surrounding residues in TMs III, IV, and V (Figure 4C). If the lid moved aside to reveal the binding pocket in simulation, numerous of such contacts broke. We thus hypothesized that L209EL2 functions to be